Potential therapeutic effects of silymarin and silymarin-loaded solid lipid nanoparticles on experimental kidney damage in BALB/c mice: biochemical and histopathological evaluation
نویسندگان
چکیده
Mustafa CENGİZ, Adnan AYHANCI, Hatice Mehtap KUTLU*, Ahmet MUSMUL Department of Elementary Education, Siirt University, Siirt, Turkey Department of Biology, Faculty of Arts and Science, Eskişehir Osmangazi University, Eskişehir, Turkey Department of Biology, Faculty of Science, Anadolu University, Eskişehir, Turkey Department of Biostatistics, Faculty of School Medicine, Eskişehir Osmangazi University, Eskişehir, Turkey
منابع مشابه
Genotoxic and Antigenotoxic Activity of Silymarin by an In Vivo Bone Marrow Micronucleus Assay and Comet Assay
Introduction: Silymarin is obtained from Silybum marianum (milk thistle), an edible plant that has long been used medicinally for the treatment of liver-related disorders. Silymarin is a powerful hepatoprotective and antioxidant but the anticlastogenic activity, which is an important aspect of its cancer chemoprevention is not known hence the present investigation was carried out to study its...
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Hepatoprotective efficacy of propolis extract (honeybee hive product, 200 mg/kg, p.o.) was studied against carbon-tetrachloride-(CCl 4, 0.15 ml/kg, i.p.) induced biochemical and histopathological changes. Silymarin, a known hepatoprotective drug was used as a positive control. Subchronic exposure to CCl 4 for 3 weeks (5 days a week) caused sharp elevation in the activity of liver enzymes i.e...
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Staphylococcus aureus is an opportunistic pathogen and remains a common cause of burn wound infections. Different studies have shown that entrapment of plant-derived compounds into liposomes could increase their anti-Staphylococcus aureus activity. Silymarin is the bioactive extract from the known plant Silybum marianum L. The objective of this study was to evaluate efficacy of silymarin in fre...
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Objective(s): The aim of this work was to prepare and characterize magnetic nanoparticles (MNPs) as theranostic system to act simultaneously as drug carrier and MRI contrast agent. Chitosan-coated MNPs (CMNPs) were prepared and loaded with silymarin. Silymarin-loaded CMNPs were characterized with various techniques and their potential as MRI contrast agent was also evaluated. Materials and Meth...
متن کاملIn-vitro and In-vivo Evaluation of Silymarin Nanoliposomes against Isolated Methicillin-resistant Staphylococcus aureus
Staphylococcus aureus is an opportunistic pathogen and remains a common cause of burn wound infections. Different studies have shown that entrapment of plant-derived compounds into liposomes could increase their anti-Staphylococcus aureus activity. Silymarin is the bioactive extract from the known plant Silybum marianum L. The objective of this study was to evaluate efficacy of silymarin in fre...
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